00:00 Disclaimer
00:15 Introduction to technology & our goal
01:00 Why nanopore? And accuracy improvements
04:43 How does nanopore sequencing work?
05:47 How can we drive improvements in accuracy and output
08:05 The Nanopore product family
08:35 Accuracy improvements — From the R10.3 to R10.4 nanopores
09:19 PromethION accuracy improvements
09:57 PromethION output (10 Tb of data from a single run)
10:57 Marathon chips: design changes to PromethION Flow Cells
12:41 P2: Low-cost, high-throughput sequencing
13:52 Introduction to Flongle
16:10 Development of our low-cost Flongle Flow Cell
18:05 Can we remove the need for users to flush their flow cell in the future?
19:06 New ASIC and future applications
22:35 Innovation at Oxford Nanopore and how we do it
23:31 Accuracy — the different ways of thinking
24:54 What can affect accuracy?
25:40 A history of nanopore accuracy
27:03 Accuracy — where are we now?
27:38 Duplex accuracy
28:37 Consensus accuracy
29:20 Variant calling…